DI were identified in 84% of these prescriptions. The frequency of indication for reversal of excessive sedation was approximately 1.3 prescriptions per 1,000 patients. Through the observational method, prescriptions and medical records of 31 patients admitted from June 2008 to June2010 were analyzed concerning the indication for flumazenil, factors that may have contributed to poisoning by benzodiazepines and frequency of DI. This study focuses on aspects related to the use of flumazenil in hospitalized patients. E-mail: ĪBSTRACT: Drug interactions (DI) exacerbate the risk of serious adverse events related to the use of benzodiazepines. E-mail: PhD in Public Health, Associate Professor, Pharmacy School, Federal University of Rio de Janeiro. E-mail: Master in Public Health, Risk Manager of the University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro. E-mail: PhD in Public Health, Public Health Technologist at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. ![]() IPharmacist, Specialist in Hospital Pharmacy, Master Student in Applied Science for Health products, Pharmacy School, Federal University Fluminense. Valcieny de Souza Sandes I Guacira Corrêa de Matos II RosanyBochner III Sônia Maria Cezar Góes IV Elisangela da Costa Lima-Dellamora V Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients.Factors related to the use of flumazenil in hospitalized patients baclofen drug reversal, alcohol withdrawal syndrome treatment, hepatic encephalopathy, cannabis toxicity, etc.) For this reason, there are several non-FDA approved uses (eg. However, flumazenil also works to reverse non-benzodiazepine substances that interact with GABA/benzodiazepine receptor complex. Method of Action:Flumazenil is a benzodiazepine antagonist. MAX cumulative: The LOWEST of 1 mg or 0.05 mg/kg ![]() Initial dose: 0.01 mg/kg (MAX 0.2 mg) given over 15 secondsįollowed by: Same dose every 1 minute for up to 4 additional doses. Pediatric greater than or equal to 1 year old: If sedation reoccurs: 0.2 mg IV may be given at 20-minute intervals Head injuries or altered cerebral blood flowīenzodiazepine reversal can provoke panic attacks in those with panic disorders ![]() Patients exhibiting signs of tricyclic antidepressants overdose Reversal of benzodiazepines may provoke convulsions/seizures in: Toxicity would most likely manifest as seizures, dysrhythmias, and hypotension Overdose/Toxicity – overdose of flumazenil is extremely rare and wouldn’t be expected in a patient that does NOT have a benzodiazepine dependence. Those receiving Romazicon should be monitored for at least 2 hours. Seizure risk – reversal of benzodiazepines can result in seizures, especially in those who use benzodiazepines to manage seizures. ![]() This suggest possible antagonism of inhaled anesthetics or even restorative affects of the drug itself.Įxpiration – Flumazenil is only stable for 24 hours if drawn into a syringe or mixed with LR, NS, or D5W Therapeutic Effects:Benzodiazepine ReversalĪnesthesia reversal – administration of 0.3 mg at the end of surgery (in patients that did NOT receive benzodiazepines) has resulted in earlier emergence and higher BIS values.
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